DHKZCOL-DBM is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms. True to its name and as an acid-extracted organic matrix from bone sources, DBM retains much of the proteinaceous components native to bone, with small amounts of calcium-based solids, inorganic phosphates and some trace cell debris. Many of DBM's proteinaceous components (e.g., growth factors) are known to be potent osteogenic agents. DBM provides a degradable matrix facilitating endogenous release of these compounds to the bone wound sites where it is surgically placed to fill bone defects, inducing new bone formation and accelerating healing. Given DBM's long clinical track record and commercial accessibility in standard forms and sources, opportunities to further develop and validate DBM as a versatile bone biomaterial in orthopedic repair and regenerative medicine contexts are attractive.

• DHKZCOL-DBM stimulates mesenchymal cell migration, activation of mitogenic factor promotes cellular proliferation, and activation of an inductive factor engenders cellular differentiation.

• DHKZCOL-DBM helps in greater osteoinduction at the orthopedic/ skeletal defective sites.

• DHKZCOL-DBM is more comfortable due to its biocompatibility.

• Since the particles are prepared from bone it acts like an osteoinductive material.

• Easily Moldable and capable of attracting appropriate tissue regenerative cells.

• Fully Resorbable matrix augumenting bone growth and promoting the formation of native bone.

• Osteonductive & osteoconductive for better bioactivity.

• Safe and effective.